Down-regulation of Mcl-1 through GSK-3β activation contributes to arsenic trioxide-induced apoptosis in acute myeloid leukemia cells

Arsenic trioxide (ATO) induces disease remission in acute promyelocytic leukemia (APL) patients, but not in non-APL acute myeloid leukemia (AML) patients. ATO at therapeutic concentrations (1-2 μM) induce APL NB4, but not non-APL HL-60, cells to undergo apoptosis through the mitochondrial pathway. T...

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Detalles Bibliográficos
Autores principales: Wang, Rui, Xia, Lijuan, Gabrilove, Janice, Waxman, Samuel, Jing, Yongkui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478411/
https://www.ncbi.nlm.nih.gov/pubmed/22751450
http://dx.doi.org/10.1038/leu.2012.180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478411/
https://www.ncbi.nlm.nih.gov/pubmed/22751450
http://dx.doi.org/10.1038/leu.2012.180

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