Mitochondrial Fission Induces Glycolytic Reprogramming in Cancer-Associated Myofibroblasts, Driving Stromal Lactate Production, and Early Tumor Growth

Recent studies have suggested that cancer cells behave as metabolic parasites, by inducing oxidative stress in adjacent normal fibroblasts. More specifically, oncogenic mutations in cancer cells lead to ROS production and the “secretion” of hydrogen peroxide species. Oxidative stress in stromal fibr...

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Detalles Bibliográficos
Autores principales: Guido, Carmela, Whitaker-Menezes, Diana, Lin, Zhao, Pestell, Richard G., Howell, Anthony, Zimmers, Teresa A., Casimiro, Mathew C., Aquila, Saveria, Ando’, Sebastiano, Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478457/
https://www.ncbi.nlm.nih.gov/pubmed/22878233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478457/
https://www.ncbi.nlm.nih.gov/pubmed/22878233

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