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Cytotoxic Mechanisms Employed by Mouse T Cells to Destroy Pancreatic β-Cells

Several cytotoxic mechanisms have been attributed to T cells participating in β-cell death in type 1 diabetes. However, sensitivity of β-cells to these mechanisms in vitro and in vivo is likely to be different. Moreover, CD4(+) and CD8(+) T cells may use distinct mechanisms to cause β-cell demise th...

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Detalles Bibliográficos
Autores principales:	Varanasi, Vineeth, Avanesyan, Lia, Schumann, Desiree M., Chervonsky, Alexander V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2012
Materias:	Immunology and Transplantation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478530/ https://www.ncbi.nlm.nih.gov/pubmed/22773667 http://dx.doi.org/10.2337/db11-1784

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