The Critical Role of Redox Homeostasis in Shikonin-Induced HL-60 Cell Differentiation via Unique Modulation of the Nrf2/ARE Pathway

Among various cancer cell lines, the leukemia cell line HL-60 was most sensitive to Shikonin, with evidence showing both the prooxidative activities and proapoptotic effects of micromolar concentrations of Shikonin. However, the mechanism involved in the cytotoxicity of Shikonin in the submicromolar...

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Detalles Bibliográficos
Autores principales: Zhang, Bo, Chen, Na, Chen, Hongmei, Wang, Zhenhua, Zheng, Qiusheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478756/
https://www.ncbi.nlm.nih.gov/pubmed/23119122
http://dx.doi.org/10.1155/2012/781516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478756/
https://www.ncbi.nlm.nih.gov/pubmed/23119122
http://dx.doi.org/10.1155/2012/781516

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