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Tryptophan hydroxylase-1 regulates immune tolerance and inflammation

Nutrient deprivation based on the loss of essential amino acids by catabolic enzymes in the microenvironment is a critical means to control inflammatory responses and immune tolerance. Here we report the novel finding that Tph-1 (tryptophan hydroxylase-1), a synthase which catalyses the conversion o...

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Detalles Bibliográficos
Autores principales: Nowak, Elizabeth C., de Vries, Victor C., Wasiuk, Anna, Ahonen, Cory, Bennett, Kathryn A., Le Mercier, Isabelle, Ha, Dae-Gon, Noelle, Randolph J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478935/
https://www.ncbi.nlm.nih.gov/pubmed/23008335
http://dx.doi.org/10.1084/jem.20120408