L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-X(L)

BACKGROUND: Mutations or deletions in DJ-1/PARK7 gene are causative for recessive forms of early onset Parkinson’s disease (PD). Wild-type DJ-1 has cytoprotective roles against cell death through multiple pathways. The most commonly studied mutant DJ-1(L166P) shifts its subcellular distribution to m...

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Detalles Bibliográficos
Autores principales: Ren, Haigang, Fu, Kai, Mu, Chenchen, Zhen, Xuechu, Wang, Guanghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479024/
https://www.ncbi.nlm.nih.gov/pubmed/22892098
http://dx.doi.org/10.1186/1750-1326-7-40

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479024/
https://www.ncbi.nlm.nih.gov/pubmed/22892098
http://dx.doi.org/10.1186/1750-1326-7-40

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