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L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-X(L)
BACKGROUND: Mutations or deletions in DJ-1/PARK7 gene are causative for recessive forms of early onset Parkinson’s disease (PD). Wild-type DJ-1 has cytoprotective roles against cell death through multiple pathways. The most commonly studied mutant DJ-1(L166P) shifts its subcellular distribution to m...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479024/ https://www.ncbi.nlm.nih.gov/pubmed/22892098 http://dx.doi.org/10.1186/1750-1326-7-40 |