Structural Basis of Type 2A von Willebrand Disease Investigated by Molecular Dynamics Simulations and Experiments

The hemostatic function of von Willebrand factor is downregulated by the metalloprotease ADAMTS13, which cleaves at a unique site normally buried in the A2 domain. Exposure of the proteolytic site is induced in the wild-type by shear stress as von Willebrand factor circulates in blood. Mutations in...

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Detalles Bibliográficos
Autores principales: Interlandi, Gianluca, Ling, Minhua, Tu, An Yue, Chung, Dominic W., Thomas, Wendy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479114/
https://www.ncbi.nlm.nih.gov/pubmed/23110044
http://dx.doi.org/10.1371/journal.pone.0045207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479114/
https://www.ncbi.nlm.nih.gov/pubmed/23110044
http://dx.doi.org/10.1371/journal.pone.0045207

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