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Structural Basis of Type 2A von Willebrand Disease Investigated by Molecular Dynamics Simulations and Experiments
The hemostatic function of von Willebrand factor is downregulated by the metalloprotease ADAMTS13, which cleaves at a unique site normally buried in the A2 domain. Exposure of the proteolytic site is induced in the wild-type by shear stress as von Willebrand factor circulates in blood. Mutations in...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479114/ https://www.ncbi.nlm.nih.gov/pubmed/23110044 http://dx.doi.org/10.1371/journal.pone.0045207 |