Diverse Small Molecule Inhibitors of Human Apurinic/Apyrimidinic Endonuclease APE1 Identified from a Screen of a Large Public Collection

The major human apurinic/apyrimidinic endonuclease APE1 plays a pivotal role in the repair of base damage via participation in the DNA base excision repair (BER) pathway. Increased activity of APE1, often observed in tumor cells, is thought to contribute to resistance to various anticancer drugs, wh...

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Detalles Bibliográficos
Autores principales: Dorjsuren, Dorjbal, Kim, Daemyung, Vyjayanti, Vaddadi N., Maloney, David J., Jadhav, Ajit, Wilson, David M., Simeonov, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479139/
https://www.ncbi.nlm.nih.gov/pubmed/23110144
http://dx.doi.org/10.1371/journal.pone.0047974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479139/
https://www.ncbi.nlm.nih.gov/pubmed/23110144
http://dx.doi.org/10.1371/journal.pone.0047974

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