Targeting a pre-mRNA structure with bipartite antisense molecules modulates tau alternative splicing

Approximately 15% of human genetic diseases are estimated to involve dysregulation of alternative pre-mRNA splicing. Antisense molecules designed to alter these and other splicing events typically target continuous linear sequences of the message. Here, we show that a structural feature in a pre-mRN...

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Detalles Bibliográficos
Autores principales: Peacey, Eleanor, Rodriguez, Lilia, Liu, Yang, Wolfe, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479178/
https://www.ncbi.nlm.nih.gov/pubmed/22844088
http://dx.doi.org/10.1093/nar/gks710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479178/
https://www.ncbi.nlm.nih.gov/pubmed/22844088
http://dx.doi.org/10.1093/nar/gks710

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