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Targeting a pre-mRNA structure with bipartite antisense molecules modulates tau alternative splicing
Approximately 15% of human genetic diseases are estimated to involve dysregulation of alternative pre-mRNA splicing. Antisense molecules designed to alter these and other splicing events typically target continuous linear sequences of the message. Here, we show that a structural feature in a pre-mRN...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479178/ https://www.ncbi.nlm.nih.gov/pubmed/22844088 http://dx.doi.org/10.1093/nar/gks710 |