Histone dosage regulates DNA damage sensitivity in a checkpoint-independent manner by the homologous recombination pathway

In eukaryotes, multiple genes encode histone proteins that package genomic deoxyribonucleic acid (DNA) and regulate its accessibility. Because of their positive charge, ‘free’ (non-chromatin associated) histones can bind non-specifically to the negatively charged DNA and affect its metabolism, inclu...

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Detalles Bibliográficos
Autores principales: Liang, Dun, Burkhart, Sarah Lyn, Singh, Rakesh Kumar, Kabbaj, Marie-Helene Miquel, Gunjan, Akash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479188/
https://www.ncbi.nlm.nih.gov/pubmed/22850743
http://dx.doi.org/10.1093/nar/gks722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479188/
https://www.ncbi.nlm.nih.gov/pubmed/22850743
http://dx.doi.org/10.1093/nar/gks722

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