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Histone dosage regulates DNA damage sensitivity in a checkpoint-independent manner by the homologous recombination pathway
In eukaryotes, multiple genes encode histone proteins that package genomic deoxyribonucleic acid (DNA) and regulate its accessibility. Because of their positive charge, ‘free’ (non-chromatin associated) histones can bind non-specifically to the negatively charged DNA and affect its metabolism, inclu...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479188/ https://www.ncbi.nlm.nih.gov/pubmed/22850743 http://dx.doi.org/10.1093/nar/gks722 |