Multimeric BLM is dissociated upon ATP hydrolysis and functions as monomers in resolving DNA structures

Bloom (BLM) syndrome is an autosomal recessive disorder characterized by an increased risk for many types of cancers. Previous studies have shown that BLM protein forms a hexameric ring structure, but its oligomeric form in DNA unwinding is still not well clarified. In this work, we have used dynami...

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Detalles Bibliográficos
Autores principales: Xu, Ya-Nan, Bazeille, Nicolas, Ding, Xiu-Yan, Lu, Xi-Ming, Wang, Peng-Ye, Bugnard, Elisabeth, Grondin, Virginie, Dou, Shuo-Xing, Xi, Xu Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479192/
https://www.ncbi.nlm.nih.gov/pubmed/22885301
http://dx.doi.org/10.1093/nar/gks728

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