Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor

Arginine methylation of histones is a well-known regulator of gene expression. Protein arginine methyltransferase 6 (PRMT6) has been shown to function as a transcriptional repressor by methylating the histone H3 arginine 2 [H3R2(me2a)] repressive mark; however, few targets are known. To define the p...

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Detalles Bibliográficos
Autores principales: Neault, Mathieu, Mallette, Frédérick A., Vogel, Gillian, Michaud-Levesque, Jonathan, Richard, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479207/
https://www.ncbi.nlm.nih.gov/pubmed/22904064
http://dx.doi.org/10.1093/nar/gks764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479207/
https://www.ncbi.nlm.nih.gov/pubmed/22904064
http://dx.doi.org/10.1093/nar/gks764

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