Rhythmic binding of Topoisomerase I impacts on the transcription of Bmal1 and circadian period

The Bmal1 gene is essential for the circadian system, and its promoter has a unique open chromatin structure. We examined the mechanism of topoisomerase I (Top1) to understand the role of the unique chromatin structure in Bmal1 gene regulation. Camptothecin, a Top1 inhibitor, and Top1 small interfer...

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Detalles Bibliográficos
Autores principales: Onishi, Yoshiaki, Kawano, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479213/
https://www.ncbi.nlm.nih.gov/pubmed/22904072
http://dx.doi.org/10.1093/nar/gks779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479213/
https://www.ncbi.nlm.nih.gov/pubmed/22904072
http://dx.doi.org/10.1093/nar/gks779

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