GSK3β inhibition blocks melanoma cell/host interactions by downregulating N-cadherin expression and decreasing FAK phosphorylation

This study addresses the role of glycogen synthase kinase (GSK)-3β signaling in the tumorigenic behavior of melanoma. Immunohistochemical staining revealed GSK3β to be focally expressed in the invasive portions of 12% and 33% of primary and metastatic melanomas, respectively. GSK3 inhibitors and siR...

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Detalles Bibliográficos
Autores principales: John, Jobin K., Paraiso, Kim H.T., Rebecca, Vito W., Cantini, Liliana P., Abel, Ethan V., Pagano, Nicholas, Meggers, Eric, Mathew, Rahel, Krepler, Clemens, Izumi, Victoria, Fang, Bin, Koomen, John M., Messina, Jane L., Herlyn, Meenhard, Smalley, Keiran S. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479306/
https://www.ncbi.nlm.nih.gov/pubmed/22810307
http://dx.doi.org/10.1038/jid.2012.237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479306/
https://www.ncbi.nlm.nih.gov/pubmed/22810307
http://dx.doi.org/10.1038/jid.2012.237

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