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Potential Role of Kringle-Integrin Interaction in Plasmin and uPA Actions (A Hypothesis)
We previously showed that the kringle domains of plasmin and angiostatin, the N-terminal four kringles (K1–4) of plasminogen, directly bind to integrins. Angiostatin blocks tumor-mediated angiogenesis and has great therapeutic potential. Angiostatin binding to integrins may be related to the antiinf...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Hindawi Publishing Corporation
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480031/ https://www.ncbi.nlm.nih.gov/pubmed/23125522 http://dx.doi.org/10.1155/2012/136302 |