Covalent Modification of Mutant Rat P2X2 Receptors with a Thiol-Reactive Fluorophore Allows Channel Activation by Zinc or Acidic pH without ATP

Rat P2X2 receptors open at an undetectably low rate in the absence of ATP. Furthermore, two allosteric modulators, zinc and acidic pH, cannot by themselves open these channels. We describe here the properties of a mutant receptor, K69C, before and after treatment with the thiol-reactive fluorophore...

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Detalles Bibliográficos
Autores principales: Dellal, Shlomo S., Hume, Richard I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480388/
https://www.ncbi.nlm.nih.gov/pubmed/23112811
http://dx.doi.org/10.1371/journal.pone.0047147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480388/
https://www.ncbi.nlm.nih.gov/pubmed/23112811
http://dx.doi.org/10.1371/journal.pone.0047147

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