MeCP2 Dependent Heterochromatin Reorganization during Neural Differentiation of a Novel Mecp2-Deficient Embryonic Stem Cell Reporter Line

The X-linked Mecp2 is a known interpreter of epigenetic information and mutated in Rett syndrome, a complex neurological disease. MeCP2 recruits HDAC complexes to chromatin thereby modulating gene expression and, importantly regulates higher order heterochromatin structure. To address the effects of...

Descripción completa

Detalles Bibliográficos
Autores principales: Bertulat, Bianca, De Bonis, Maria Luigia, Della Ragione, Floriana, Lehmkuhl, Anne, Milden, Manuela, Storm, Christian, Jost, K. Laurence, Scala, Simona, Hendrich, Brian, D’Esposito, Maurizio, Cardoso, M. Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480415/
https://www.ncbi.nlm.nih.gov/pubmed/23112857
http://dx.doi.org/10.1371/journal.pone.0047848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480415/
https://www.ncbi.nlm.nih.gov/pubmed/23112857
http://dx.doi.org/10.1371/journal.pone.0047848

Ejemplares similares