Metabolic Profiling Reveals Sphingosine-1-Phosphate Kinase 2 and Lyase as Key Targets of (Phyto-) Estrogen Action in the Breast Cancer Cell Line MCF-7 and Not in MCF-12A

To search for new targets of anticancer therapies using phytoestrogens we performed comparative metabolic profiling of the breast cancer cell line MCF-7 and the non-tumorigenic breast cell line MCF-12A. Application of gas chromatography-mass spectrometry (GC-MS) revealed significant differences in t...

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Detalles Bibliográficos
Autores principales: Engel, Nadja, Lisec, Jan, Piechulla, Birgit, Nebe, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480432/
https://www.ncbi.nlm.nih.gov/pubmed/23112854
http://dx.doi.org/10.1371/journal.pone.0047833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480432/
https://www.ncbi.nlm.nih.gov/pubmed/23112854
http://dx.doi.org/10.1371/journal.pone.0047833

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