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Positive and negative selection, self-nonself discrimination and the roles of costimulation and anergy
It is still unclear whether the adaptive immune system can perform accurate self-nonself discrimination and what could influence its performance. Starting from simple cellular interaction rules we show that it is possible to achieve perfect self-nonself discrimination in a consistent framework provi...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480656/ https://www.ncbi.nlm.nih.gov/pubmed/23101027 http://dx.doi.org/10.1038/srep00769 |