Structure and Ligand Based Drug Design Strategies in the Development of Novel 5-LOX Inhibitors

Lipoxygenases (LOXs) are non-heme iron containing dioxygenases involved in the oxygenation of polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA). Depending on the position of insertion of oxygen, LOXs are classified into 5-, 8-, 9-, 12- and 15-LOX. Among these, 5-LOX is the most predo...

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Detalles Bibliográficos
Autores principales: Aparoy, Polamarasetty, Kumar Reddy, Kakularam, Reddanna, Pallu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480706/
https://www.ncbi.nlm.nih.gov/pubmed/22680930
http://dx.doi.org/10.2174/092986712801661112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480706/
https://www.ncbi.nlm.nih.gov/pubmed/22680930
http://dx.doi.org/10.2174/092986712801661112

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