Antidepressant-like activity of (4-phenylpiperazin-1-yl) (quinoxalin-2-yl) methanone (4a), a novel 5-HT(3) receptor antagonist: An investigation in behaviour-based rodent models of depression

AIM: The present study was designed to investigate the antidepressant potential of (4-phenylpiperazin-1-yl) (quinoxalin-3-yl) methanone (4a), a novel 5-HT(3) receptor antagonist, with an optimal log P (2.84) and pA(2) value (7.3) greater than ondansetron (6.9) using rodent behavioural models of depr...

Descripción completa

Detalles Bibliográficos
Autores principales: Mahesh, Radhakrishnan, Kumar, Baldev, Jindal, Ankur, Bhatt, Shvetank, Devadoss, Thangaraj, Pandey, Dilip Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480784/
https://www.ncbi.nlm.nih.gov/pubmed/23112413
http://dx.doi.org/10.4103/0253-7613.100371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480784/
https://www.ncbi.nlm.nih.gov/pubmed/23112413
http://dx.doi.org/10.4103/0253-7613.100371

Ejemplares similares