Effects of pravastatin on the pharmacokinetic parameters of nimodipine after oral and intravenous administration in rats: Possible role of CYP3A4 inhibition by pravastatin

OBJECTIVE: The aim of this study was to investigate the effects of pravastatin on the pharmacokinetics of nimodipine in rats. MATERIALS AND METHODS: The effect of pravastatin on P-glycoprotein (P-gp) and cytochrome P450 (CYP) 3A4 activity was evaluated. Nimodipine was administered to rats intravenou...

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Detalles Bibliográficos
Autores principales: Lee, Chong-Ki, Choi, Jun-Shik, Choi, Dong-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480797/
https://www.ncbi.nlm.nih.gov/pubmed/23112426
http://dx.doi.org/10.4103/0253-7613.100395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480797/
https://www.ncbi.nlm.nih.gov/pubmed/23112426
http://dx.doi.org/10.4103/0253-7613.100395

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