Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor

There is significant interest in treating cancers by blocking protein synthesis, to which hematological malignancies seem particularly sensitive. The translation elongation inhibitor homoharringtonine (Omacetaxine mepesuccinate) is undergoing clinical trials for chronic myeloid leukemia, whereas the...

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Detalles Bibliográficos
Autores principales: Lindqvist, L M, Vikström, I, Chambers, J M, McArthur, K, Ann Anderson, M, Henley, K J, Happo, L, Cluse, L, Johnstone, R W, Roberts, A W, Kile, B T, Croker, B A, Burns, C J, Rizzacasa, M A, Strasser, A, Huang, DC S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481137/
https://www.ncbi.nlm.nih.gov/pubmed/23059828
http://dx.doi.org/10.1038/cddis.2012.149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481137/
https://www.ncbi.nlm.nih.gov/pubmed/23059828
http://dx.doi.org/10.1038/cddis.2012.149

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