Intraocular pressure variation in patients on long-term corticosteroids

BACKGROUND: Long-term use of topical and systemic steroids produces secondary open-angle glaucoma similar to chronic simple glaucoma. The increased intraocular pressure [IOP] caused by prolonged steroid therapy is reversible but the damage produced by it is irreversible. MATERIALS AND METHODS: In th...

Descripción completa

Detalles Bibliográficos
Autores principales: Mandapati, John Shekhar Raju, Metta, Arun Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications Pvt Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481806/
https://www.ncbi.nlm.nih.gov/pubmed/23130227
http://dx.doi.org/10.4103/2229-5178.85993
_version_ 1782247798531424256
author Mandapati, John Shekhar Raju
Metta, Arun Kumar
author_facet Mandapati, John Shekhar Raju
Metta, Arun Kumar
author_sort Mandapati, John Shekhar Raju
collection PubMed
description BACKGROUND: Long-term use of topical and systemic steroids produces secondary open-angle glaucoma similar to chronic simple glaucoma. The increased intraocular pressure [IOP] caused by prolonged steroid therapy is reversible but the damage produced by it is irreversible. MATERIALS AND METHODS: In this study, we analyzed 200 patients with steroid-induced glaucoma, who were on systemic and topical corticosteroids for various dermatological conditions. The variation in IOP caused by different steroid preparations was studied. RESULTS: Two hundred patients who were on systemic steroids for more than 8 weeks developed raised IOP. Three of these patients also developed bilateral posterior subcapsular cataract. CONCLUSION: We conclude that systemic steroids can induce rise of IOP and cataract formation. If it is not detected and treated in time, rise in IOP can lead to irreversible damage to the eyes.
format Online
Article
Text
id pubmed-3481806
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Medknow Publications Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-34818062012-11-05 Intraocular pressure variation in patients on long-term corticosteroids Mandapati, John Shekhar Raju Metta, Arun Kumar Indian Dermatol Online J Original Article BACKGROUND: Long-term use of topical and systemic steroids produces secondary open-angle glaucoma similar to chronic simple glaucoma. The increased intraocular pressure [IOP] caused by prolonged steroid therapy is reversible but the damage produced by it is irreversible. MATERIALS AND METHODS: In this study, we analyzed 200 patients with steroid-induced glaucoma, who were on systemic and topical corticosteroids for various dermatological conditions. The variation in IOP caused by different steroid preparations was studied. RESULTS: Two hundred patients who were on systemic steroids for more than 8 weeks developed raised IOP. Three of these patients also developed bilateral posterior subcapsular cataract. CONCLUSION: We conclude that systemic steroids can induce rise of IOP and cataract formation. If it is not detected and treated in time, rise in IOP can lead to irreversible damage to the eyes. Medknow Publications Pvt Ltd 2011 /pmc/articles/PMC3481806/ /pubmed/23130227 http://dx.doi.org/10.4103/2229-5178.85993 Text en Copyright: © Indian Dermatology Online Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Mandapati, John Shekhar Raju
Metta, Arun Kumar
Intraocular pressure variation in patients on long-term corticosteroids
title Intraocular pressure variation in patients on long-term corticosteroids
title_full Intraocular pressure variation in patients on long-term corticosteroids
title_fullStr Intraocular pressure variation in patients on long-term corticosteroids
title_full_unstemmed Intraocular pressure variation in patients on long-term corticosteroids
title_short Intraocular pressure variation in patients on long-term corticosteroids
title_sort intraocular pressure variation in patients on long-term corticosteroids
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481806/
https://www.ncbi.nlm.nih.gov/pubmed/23130227
http://dx.doi.org/10.4103/2229-5178.85993
work_keys_str_mv AT mandapatijohnshekharraju intraocularpressurevariationinpatientsonlongtermcorticosteroids
AT mettaarunkumar intraocularpressurevariationinpatientsonlongtermcorticosteroids