NGF Inhibits Human Leukemia Proliferation by Downregulating Cyclin A1 Expression through Promoting Acinus/CtBP2 Association

Cyclin A1 is essential for leukemia progression, and its expression is tightly regulated by acinus, a nuclear speckle protein. However, the molecular mechanism of how acinus mediates cyclin A1 expression remains elusive. Here we show that transcription corepressor CtBP2 directly binds acinus, which...

Descripción completa

Detalles Bibliográficos
Autores principales: Chan, Chi Bun, Liu, Xia, Jang, Sung-Wuk, Hsu, Stephen I-Hong, Williams, Ifor, Kang, Sumin, Chen, Jing, Ye, Keqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481846/
https://www.ncbi.nlm.nih.gov/pubmed/19668232
http://dx.doi.org/10.1038/onc.2009.236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481846/
https://www.ncbi.nlm.nih.gov/pubmed/19668232
http://dx.doi.org/10.1038/onc.2009.236

Ejemplares similares