Loss of RBPj in Postnatal Excitatory Neurons Does Not Cause Neurodegeneration or Memory Impairments in Aged Mice

Previous studies suggest that loss of γ-secretase activity in postnatal mouse brains causes age-dependent memory impairment and neurodegeneration. Due to the diverse array of γ-secretase substrates, it remains to be demonstrated whether loss of cleavage of any specific substrate(s) is responsible fo...

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Detalles Bibliográficos
Autores principales: Sato, Chihiro, Turkoz, Mustafa, Dearborn, Joshua T., Wozniak, David F., Kopan, Raphael, Hass, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482205/
https://www.ncbi.nlm.nih.gov/pubmed/23110206
http://dx.doi.org/10.1371/journal.pone.0048180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482205/
https://www.ncbi.nlm.nih.gov/pubmed/23110206
http://dx.doi.org/10.1371/journal.pone.0048180

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