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ER Stress Activates NF-κB by Integrating Functions of Basal IKK Activity, IRE1 and PERK
NF-κB, a transcription factor, becomes activated during the Unfolded Protein Response (UPR), an endoplasmic reticulum (ER) stress response pathway. NF-κB is normally held inactive by its inhibitor, IκBα. Multiple cellular pathways activate IKK (IκBα Kinase) which phosphorylate IκBα leading to its de...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482226/ https://www.ncbi.nlm.nih.gov/pubmed/23110043 http://dx.doi.org/10.1371/journal.pone.0045078 |