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A Bioinformatics Method Identifies Prominent Off-targeted Transcripts in RNAi Screens
Because off-target effects hamper interpretation and validation of RNAi screens, we developed a bioinformatics method, Genome-wide Enrichment of Seed Sequence matches (GESS), to identify candidate off-targeted transcripts from direct analysis of primary screening data. GESS identified a prominent of...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482495/ https://www.ncbi.nlm.nih.gov/pubmed/22343343 http://dx.doi.org/10.1038/nmeth.1898 |