Failure of Amino Acid Homeostasis Causes Cell Death following Proteasome Inhibition

The ubiquitin-proteasome system targets many cellular proteins for degradation and thereby controls most cellular processes. Although it is well established that proteasome inhibition is lethal, the underlying mechanism is unknown. Here, we show that proteasome inhibition results in a lethal amino a...

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Detalles Bibliográficos
Autores principales: Suraweera, Amila, Münch, Christian, Hanssum, Ariane, Bertolotti, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482661/
https://www.ncbi.nlm.nih.gov/pubmed/22959274
http://dx.doi.org/10.1016/j.molcel.2012.08.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482661/
https://www.ncbi.nlm.nih.gov/pubmed/22959274
http://dx.doi.org/10.1016/j.molcel.2012.08.003

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