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Failure of Amino Acid Homeostasis Causes Cell Death following Proteasome Inhibition
The ubiquitin-proteasome system targets many cellular proteins for degradation and thereby controls most cellular processes. Although it is well established that proteasome inhibition is lethal, the underlying mechanism is unknown. Here, we show that proteasome inhibition results in a lethal amino a...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482661/ https://www.ncbi.nlm.nih.gov/pubmed/22959274 http://dx.doi.org/10.1016/j.molcel.2012.08.003 |