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Molecular architecture of human polycomb repressive complex 2

Polycomb Repressive Complex 2 (PRC2) is essential for gene silencing, establishing transcriptional repression of specific genes by tri-methylating Lysine 27 of histone H3, a process mediated by cofactors such as AEBP2. In spite of its biological importance, little is known about PRC2 architecture an...

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Detalles Bibliográficos
Autores principales: Ciferri, Claudio, Lander, Gabriel C, Maiolica, Alessio, Herzog, Franz, Aebersold, Ruedi, Nogales, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482686/
https://www.ncbi.nlm.nih.gov/pubmed/23110252
http://dx.doi.org/10.7554/eLife.00005