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The SP-C promoter facilitates alveolar type II epithelial cell-specific plasmid nuclear import and gene expression
Although nonviral gene therapy has great potential for use in the lung, the relative lack of cell-specific targeting has limited its applications. We have developed a new approach for cell-specific targeting based on selective nuclear import of plasmids in non-dividing cells. Using a microinjection...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482943/ https://www.ncbi.nlm.nih.gov/pubmed/20054353 http://dx.doi.org/10.1038/gt.2009.166 |