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Basis for allosteric open-state stabilization of voltage-gated potassium channels by intracellular cations

The open state of voltage-gated potassium (Kv) channels is associated with an increased stability relative to the pre-open closed states and is reflected by a slowing of OFF gating currents after channel opening. The basis for this stabilization is usually assigned to intrinsic structural features o...

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Detalles Bibliográficos
Autores principales: Goodchild, Samuel J., Xu, Hongjian, Es-Salah-Lamoureux, Zeineb, Ahern, Christopher A., Fedida, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483119/
https://www.ncbi.nlm.nih.gov/pubmed/23071269
http://dx.doi.org/10.1085/jgp.201210823