Cellular context and multiple channel domains determine cAMP sensitivity of HCN4 channels: Ligand-independent relief of autoinhibition in HCN4

Hyperpolarization-activated, cyclic nucleotide–sensitive (HCN) channels produce the I(f) and I(h) currents, which are critical for cardiac pacemaking and neuronal excitability, respectively. HCN channels are modulated by cyclic AMP (cAMP), which binds to a conserved cyclic nucleotide–binding domain...

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Detalles Bibliográficos
Autores principales: Liao, Zhandi, Lockhead, Dean, St. Clair, Joshua R., Larson, Eric D., Wilson, Courtney E., Proenza, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483121/
https://www.ncbi.nlm.nih.gov/pubmed/23109717
http://dx.doi.org/10.1085/jgp.201210858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483121/
https://www.ncbi.nlm.nih.gov/pubmed/23109717
http://dx.doi.org/10.1085/jgp.201210858

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