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Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells
As adhesion molecules, integrins connect a cell to its environment and transduce signals across the membrane. Their different functional states correspond to distinct conformations. Using a biomembrane force probe, we observed real-time reversible switches between bent and extended conformations of...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483124/ https://www.ncbi.nlm.nih.gov/pubmed/23109670 http://dx.doi.org/10.1083/jcb.201201091 |