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Using force to visualize conformational activation of integrins

The development of biophysical approaches to analyze integrin–ligand binding allows us to visualize in real time the conformational changes that shift the bond affinity between low- and high-affinity states. In this issue, Chen et al. (2012. J. Cell Biol. http://dx.doi.org/jcb.201201091) use these a...

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Detalles Bibliográficos
Autor principal: Boettiger, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483130/
https://www.ncbi.nlm.nih.gov/pubmed/23109668
http://dx.doi.org/10.1083/jcb.201209073
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author Boettiger, David
author_facet Boettiger, David
author_sort Boettiger, David
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description The development of biophysical approaches to analyze integrin–ligand binding allows us to visualize in real time the conformational changes that shift the bond affinity between low- and high-affinity states. In this issue, Chen et al. (2012. J. Cell Biol. http://dx.doi.org/jcb.201201091) use these approaches to validate some aspects of the classical integrin regulation model; however, their data suggest that much of the regulation occurs after ligand binding rather than in preparation for ligand binding to occur.
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spelling pubmed-34831302013-04-29 Using force to visualize conformational activation of integrins Boettiger, David J Cell Biol Reviews The development of biophysical approaches to analyze integrin–ligand binding allows us to visualize in real time the conformational changes that shift the bond affinity between low- and high-affinity states. In this issue, Chen et al. (2012. J. Cell Biol. http://dx.doi.org/jcb.201201091) use these approaches to validate some aspects of the classical integrin regulation model; however, their data suggest that much of the regulation occurs after ligand binding rather than in preparation for ligand binding to occur. The Rockefeller University Press 2012-10-29 /pmc/articles/PMC3483130/ /pubmed/23109668 http://dx.doi.org/10.1083/jcb.201209073 Text en © 2012 Boettiger This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Boettiger, David
Using force to visualize conformational activation of integrins
title Using force to visualize conformational activation of integrins
title_full Using force to visualize conformational activation of integrins
title_fullStr Using force to visualize conformational activation of integrins
title_full_unstemmed Using force to visualize conformational activation of integrins
title_short Using force to visualize conformational activation of integrins
title_sort using force to visualize conformational activation of integrins
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483130/
https://www.ncbi.nlm.nih.gov/pubmed/23109668
http://dx.doi.org/10.1083/jcb.201209073
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