Cargando…
Using force to visualize conformational activation of integrins
The development of biophysical approaches to analyze integrin–ligand binding allows us to visualize in real time the conformational changes that shift the bond affinity between low- and high-affinity states. In this issue, Chen et al. (2012. J. Cell Biol. http://dx.doi.org/jcb.201201091) use these a...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483130/ https://www.ncbi.nlm.nih.gov/pubmed/23109668 http://dx.doi.org/10.1083/jcb.201209073 |
_version_ | 1782247948296388608 |
---|---|
author | Boettiger, David |
author_facet | Boettiger, David |
author_sort | Boettiger, David |
collection | PubMed |
description | The development of biophysical approaches to analyze integrin–ligand binding allows us to visualize in real time the conformational changes that shift the bond affinity between low- and high-affinity states. In this issue, Chen et al. (2012. J. Cell Biol. http://dx.doi.org/jcb.201201091) use these approaches to validate some aspects of the classical integrin regulation model; however, their data suggest that much of the regulation occurs after ligand binding rather than in preparation for ligand binding to occur. |
format | Online Article Text |
id | pubmed-3483130 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-34831302013-04-29 Using force to visualize conformational activation of integrins Boettiger, David J Cell Biol Reviews The development of biophysical approaches to analyze integrin–ligand binding allows us to visualize in real time the conformational changes that shift the bond affinity between low- and high-affinity states. In this issue, Chen et al. (2012. J. Cell Biol. http://dx.doi.org/jcb.201201091) use these approaches to validate some aspects of the classical integrin regulation model; however, their data suggest that much of the regulation occurs after ligand binding rather than in preparation for ligand binding to occur. The Rockefeller University Press 2012-10-29 /pmc/articles/PMC3483130/ /pubmed/23109668 http://dx.doi.org/10.1083/jcb.201209073 Text en © 2012 Boettiger This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Reviews Boettiger, David Using force to visualize conformational activation of integrins |
title | Using force to visualize conformational activation of integrins |
title_full | Using force to visualize conformational activation of integrins |
title_fullStr | Using force to visualize conformational activation of integrins |
title_full_unstemmed | Using force to visualize conformational activation of integrins |
title_short | Using force to visualize conformational activation of integrins |
title_sort | using force to visualize conformational activation of integrins |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483130/ https://www.ncbi.nlm.nih.gov/pubmed/23109668 http://dx.doi.org/10.1083/jcb.201209073 |
work_keys_str_mv | AT boettigerdavid usingforcetovisualizeconformationalactivationofintegrins |