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Assessing Predictors of Changes in Protein Stability upon Mutation Using Self-Consistency

The ability to predict the effect of mutations on protein stability is important for a wide range of tasks, from protein engineering to assessing the impact of SNPs to understanding basic protein biophysics. A number of methods have been developed that make these predictions, but assessing the accur...

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Detalles Bibliográficos
Autores principales: Thiltgen, Grant, Goldstein, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483175/
https://www.ncbi.nlm.nih.gov/pubmed/23144695
http://dx.doi.org/10.1371/journal.pone.0046084