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Flexibility of EF-hand motifs: structural and thermodynamic studies of Calcium Binding Protein-1 from Entamoeba histolytica with Pb(2+), Ba(2+), and Sr(2+)

BACKGROUND: EF-hand proteins can be activated by the binding of various heavy metals other than calcium, and such complexes can disturb the calcium-signaling pathway and cause toxicity and disease causing state. So far, no comprehensive study has been done to understand different heavy metals bindin...

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Detalles Bibliográficos
Autores principales: Kumar, Shivesh, Ahmad, Ejaz, Kumar, Sanjeev, Khan, Rizwan Hasan, Gourinath, Samudrala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483242/
https://www.ncbi.nlm.nih.gov/pubmed/22906057
http://dx.doi.org/10.1186/2046-1682-5-15