Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases

BACKGROUNDS: Streptococcus pneumoniae expresses three distinct sialidases, NanA, NanB, and NanC, that are believed to be key virulence factors and thus, potential important drug targets. We previously reported that the three enzymes release different products from sialosides, but could share a commo...

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Detalles Bibliográficos
Autores principales: Hayre, Jasvinder Kaur, Xu, Guogang, Borgianni, Luisa, Taylor, Garry L, Andrew, Peter W, Docquier, Jean-Denis, Oggioni, Marco R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483245/
https://www.ncbi.nlm.nih.gov/pubmed/23031230
http://dx.doi.org/10.1186/1471-2091-13-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483245/
https://www.ncbi.nlm.nih.gov/pubmed/23031230
http://dx.doi.org/10.1186/1471-2091-13-19

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