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Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases
BACKGROUNDS: Streptococcus pneumoniae expresses three distinct sialidases, NanA, NanB, and NanC, that are believed to be key virulence factors and thus, potential important drug targets. We previously reported that the three enzymes release different products from sialosides, but could share a commo...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483245/ https://www.ncbi.nlm.nih.gov/pubmed/23031230 http://dx.doi.org/10.1186/1471-2091-13-19 |