Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors

The striatum regulates motor control, reward, and learning. Abnormal function of striatal GABAergic medium spiny neurons (MSNs) is believed to contribute to the deficits in these processes that are observed in many neuropsychiatric diseases. The orphan G-protein-coupled receptor (GPCR) GPR88 is robu...

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Detalles Bibliográficos
Autores principales: Quintana, Albert, Sanz, Elisenda, Wang, Wengang, Storey, Granville P., Güler, Ali D., Wanat, Matthew J., Roller, Bryan A., La Torre, Anna, Amieux, Paul S., McKnight, G. Stanley, Bamford, Nigel S., Palmiter, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483418/
https://www.ncbi.nlm.nih.gov/pubmed/23064379
http://dx.doi.org/10.1038/nn.3239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483418/
https://www.ncbi.nlm.nih.gov/pubmed/23064379
http://dx.doi.org/10.1038/nn.3239

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