Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression

Genome-wide association studies (GWASs) have identified thousands of single nucleotide polymorphisms (SNPs) associated with human traits and diseases. But because the vast majority of these SNPs are located in the noncoding regions of the genome their risk promoting mechanisms are elusive. Employing...

Descripción completa

Detalles Bibliográficos
Autores principales: Cowper-Sal·lari, Richard, Zhang, Xiaoyang, Wright, Jason B., Bailey, Swneke D., Cole, Michael D., Eeckhoute, Jerome, Moore, Jason H., Lupien, Mathieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483423/
https://www.ncbi.nlm.nih.gov/pubmed/23001124
http://dx.doi.org/10.1038/ng.2416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483423/
https://www.ncbi.nlm.nih.gov/pubmed/23001124
http://dx.doi.org/10.1038/ng.2416

Ejemplares similares