Modeling of Tumor Progression in NSCLC and Intrinsic Resistance to TKI in Loss of PTEN Expression

EGFR signaling plays a very important role in NSCLC. It activates Ras/ERK, PI3K/Akt and STAT activation pathways. These are the main pathways for cell proliferation and survival. We have developed two mathematical models to relate to the different EGFR signaling in NSCLC and normal cells in the pres...

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Detalles Bibliográficos
Autores principales: Bidkhori, Gholamreza, Moeini, Ali, Masoudi-Nejad, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483873/
https://www.ncbi.nlm.nih.gov/pubmed/23133538
http://dx.doi.org/10.1371/journal.pone.0048004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483873/
https://www.ncbi.nlm.nih.gov/pubmed/23133538
http://dx.doi.org/10.1371/journal.pone.0048004

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