Molecular Basis for Modulation of the p53 Target Selectivity by KLF4

The tumour suppressor p53 controls transcription of various genes involved in apoptosis, cell-cycle arrest, DNA repair and metabolism. However, its DNA-recognition specificity is not nearly sufficient to explain binding to specific locations in vivo. Here, we present evidence that KLF4 increases the...

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Detalles Bibliográficos
Autores principales: Brandt, Tobias, Townsley, Fiona M., Teufel, Daniel P., Freund, Stefan M. V., Veprintsev, Dmitry B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484126/
https://www.ncbi.nlm.nih.gov/pubmed/23118962
http://dx.doi.org/10.1371/journal.pone.0048252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484126/
https://www.ncbi.nlm.nih.gov/pubmed/23118962
http://dx.doi.org/10.1371/journal.pone.0048252

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