The cystic-fibrosis-associated ΔF508 mutation confers post-transcriptional destabilization on the C. elegans ABC transporter PGP-3

Membrane proteins make up ∼30% of the proteome. During the early stages of maturation, this class of proteins can experience localized misfolding in distinct cellular compartments, such as the cytoplasm, endoplasmic reticulum (ER) lumen and ER membrane. ER quality control (ERQC) mechanisms monitor f...

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Detalles Bibliográficos
Autores principales: He, Liping, Skirkanich, Jennifer, Moronetti, Lorenza, Lewis, Rosemary, Lamitina, Todd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2012
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484874/
https://www.ncbi.nlm.nih.gov/pubmed/22569626
http://dx.doi.org/10.1242/dmm.008987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484874/
https://www.ncbi.nlm.nih.gov/pubmed/22569626
http://dx.doi.org/10.1242/dmm.008987

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