Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems

Nonsense mutations that result in the expression of truncated, N-terminal, fragments of the adenomatous polyposis coli (APC) tumour suppressor protein are found in most sporadic and some hereditary colorectal cancers. These mutations can cause tumorigenesis by eliminating β-catenin-binding sites fro...

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Detalles Bibliográficos
Autores principales: Nelson, Scott A., Li, Zhouyu, Newton, Ian P., Fraser, David, Milne, Rachel E., Martin, David M. A., Schiffmann, David, Yang, Xuesong, Dormann, Dirk, Weijer, Cornelis J., Appleton, Paul L., Näthke, Inke S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2012
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484875/
https://www.ncbi.nlm.nih.gov/pubmed/22563063
http://dx.doi.org/10.1242/dmm.008607

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484875/
https://www.ncbi.nlm.nih.gov/pubmed/22563063
http://dx.doi.org/10.1242/dmm.008607

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